Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease
Identifieur interne : 002736 ( Main/Exploration ); précédent : 002735; suivant : 002737Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease
Auteurs : J. H. Xuereb ; E. K. Perry ; J. M. Candy ; J. R. Bonham ; R. H. Perry ; E. MarshallSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1990.
Abstract
Loss of cholinergic cells in the basal forebrain is associated with commensurate reductions in cortical acetylcholine-related enzyme activities in both Alzheimer's disease (AD) and Parkinson's disease (PD). Nerve cell loss from the cholinergic pontine tegmental nuclei also occurs. As the latter nuclei project to the diencephalon, we used frozen tissue from 5 controls, 5 PD and 5 AD cases to study the distribution of ChAT, AChE and [3H]nicotine binding in the thalamus and subthalamic nucleus. The anterior nuclear group and the mediodorsal nucleus showed high activities of ChAT and AChE together with relatively high levels of [3H]nicotine binding. The centromedian nucleus and subthalamic nucleus contained equally high levels of ChAT but negligible levels of [3H]nicotine binding. There were no significant changes in the levels of ChAT, AChE and nicotine binding in the PD and AD groups indicating that involvement of the pedunculopontine tegmental nucleus is likely to be a secondary retrograde phenomenon rather than part of a systematic cholinergic fibre degeneration.
Url:
DOI: 10.1016/0022-510X(90)90155-G
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease</title><author><name sortKey="Xuereb, J H" sort="Xuereb, J H" uniqKey="Xuereb J" first="J. H." last="Xuereb">J. H. Xuereb</name></author><author><name sortKey="Perry, E K" sort="Perry, E K" uniqKey="Perry E" first="E. K." last="Perry">E. K. Perry</name></author><author><name sortKey="Candy, J M" sort="Candy, J M" uniqKey="Candy J" first="J. M." last="Candy">J. M. Candy</name></author><author><name sortKey="Bonham, J R" sort="Bonham, J R" uniqKey="Bonham J" first="J. R." last="Bonham">J. R. Bonham</name></author><author><name sortKey="Perry, R H" sort="Perry, R H" uniqKey="Perry R" first="R. H." last="Perry">R. H. Perry</name></author><author><name sortKey="Marshall, E" sort="Marshall, E" uniqKey="Marshall E" first="E." last="Marshall">E. Marshall</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0B7BD2D3912C9AA91DD0873031B90AAA377845E8</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1016/0022-510X(90)90155-G</idno><idno type="url">https://api.istex.fr/document/0B7BD2D3912C9AA91DD0873031B90AAA377845E8/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002952</idno><idno type="wicri:Area/Main/Curation">002600</idno><idno type="wicri:Area/Main/Exploration">002736</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease</title><author><name sortKey="Xuereb, J H" sort="Xuereb, J H" uniqKey="Xuereb J" first="J. H." last="Xuereb">J. H. Xuereb</name><affiliation><wicri:noCountry code="subField">Cambridge CB2 2QQ U.K.</wicri:noCountry></affiliation></author><author><name sortKey="Perry, E K" sort="Perry, E K" uniqKey="Perry E" first="E. K." last="Perry">E. K. Perry</name><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne NE4 6BE U.K.</wicri:noCountry></affiliation></author><author><name sortKey="Candy, J M" sort="Candy, J M" uniqKey="Candy J" first="J. M." last="Candy">J. M. Candy</name><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne NE4 6BE U.K.</wicri:noCountry></affiliation></author><author><name sortKey="Bonham, J R" sort="Bonham, J R" uniqKey="Bonham J" first="J. R." last="Bonham">J. R. Bonham</name><affiliation><wicri:noCountry code="subField">Sheffield S10 2TH U.K.</wicri:noCountry></affiliation></author><author><name sortKey="Perry, R H" sort="Perry, R H" uniqKey="Perry R" first="R. H." last="Perry">R. H. Perry</name><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne NE4 6BE U.K.</wicri:noCountry></affiliation></author><author><name sortKey="Marshall, E" sort="Marshall, E" uniqKey="Marshall E" first="E." last="Marshall">E. Marshall</name><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne NE2 4AE U.K.</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">99</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="185">185</biblScope><biblScope unit="page" to="197">197</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">0B7BD2D3912C9AA91DD0873031B90AAA377845E8</idno><idno type="DOI">10.1016/0022-510X(90)90155-G</idno><idno type="PII">0022-510X(90)90155-G</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Loss of cholinergic cells in the basal forebrain is associated with commensurate reductions in cortical acetylcholine-related enzyme activities in both Alzheimer's disease (AD) and Parkinson's disease (PD). Nerve cell loss from the cholinergic pontine tegmental nuclei also occurs. As the latter nuclei project to the diencephalon, we used frozen tissue from 5 controls, 5 PD and 5 AD cases to study the distribution of ChAT, AChE and [3H]nicotine binding in the thalamus and subthalamic nucleus. The anterior nuclear group and the mediodorsal nucleus showed high activities of ChAT and AChE together with relatively high levels of [3H]nicotine binding. The centromedian nucleus and subthalamic nucleus contained equally high levels of ChAT but negligible levels of [3H]nicotine binding. There were no significant changes in the levels of ChAT, AChE and nicotine binding in the PD and AD groups indicating that involvement of the pedunculopontine tegmental nucleus is likely to be a secondary retrograde phenomenon rather than part of a systematic cholinergic fibre degeneration.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bonham, J R" sort="Bonham, J R" uniqKey="Bonham J" first="J. R." last="Bonham">J. R. Bonham</name><name sortKey="Candy, J M" sort="Candy, J M" uniqKey="Candy J" first="J. M." last="Candy">J. M. Candy</name><name sortKey="Marshall, E" sort="Marshall, E" uniqKey="Marshall E" first="E." last="Marshall">E. Marshall</name><name sortKey="Perry, E K" sort="Perry, E K" uniqKey="Perry E" first="E. K." last="Perry">E. K. Perry</name><name sortKey="Perry, R H" sort="Perry, R H" uniqKey="Perry R" first="R. H." last="Perry">R. H. Perry</name><name sortKey="Xuereb, J H" sort="Xuereb, J H" uniqKey="Xuereb J" first="J. H." last="Xuereb">J. H. Xuereb</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002736 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002736 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:0B7BD2D3912C9AA91DD0873031B90AAA377845E8
|texte= Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease
}}
| This area was generated with Dilib version V0.6.23. |  |